A contact-waiting-time metric and RNA folding rates
نویسندگان
چکیده
منابع مشابه
A contact-waiting-time metric and RNA folding rates.
Metrics for indirectly predicting the folding rates of RNA sequences are of interest. In this letter, we introduce a simple metric of RNA structural complexity, which accounts for differences in the energetic contributions of RNA base contacts toward RNA structure formation. We apply the metric to RNA sequences whose folding rates were previously determined experimentally. We find that the metr...
متن کاملProtein folding rates estimated from contact predictions.
Folding rates of small single-domain proteins that fold through simple two-state kinetics can be estimated from details of the three-dimensional protein structure. Previously, predictions of secondary structure had been exploited to predict folding rates from sequence. Here, we estimate two-state folding rates from predictions of internal residue-residue contacts in proteins of unknown structur...
متن کاملDimensions: Waiting Time Extraction of Nucleation Rates
We study the rate of true vacuum bubble nucleation numerically for a φ4 field system coupled to a source of thermal noise. We compare in detail the cases of additive and multiplicative noise. We pay special attention to the choice of initial field configuration, showing the advantages of a version of the quenching technique. We advocate a new method of extracting the nucleation time scale that ...
متن کاملTopological complexity, contact order and protein folding rates
Monte Carlo simulations of protein folding show the emergence of a strong correlation between the relative contact order parameter, CO, and the folding time, t, of two-state folding proteins for longer chains with number of amino acids, N ≥ 54, and higher contact order, CO > 0.17. The correlation is particularly strong for N = 80 corresponding to slow and more complex folding kinetics. These re...
متن کاملpassivity in waiting for godot and endgame: a psychoanalytic reading
this study intends to investigate samuel beckett’s waiting for godot and endgame under the lacanian psychoanalysis. it begins by explaining the most important concepts of lacanian psychoanalysis. the beckettian characters are studied regarding their state of unconscious, and not the state of consciousness as is common in most beckett studies. according to lacan, language plays the sole role in ...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 2009
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2009.06.038